Piperazine-2,3-dicarboxylic acid Derivatives as Dual Antagonists of NMDA and GluK1-Containing Kainate Receptors

Competitive N-methyl-D-aspartate receptor (NMDAR) antagonists bind to the GluN2 subunit, of which there are four types (GluN2A-D). We report that some N(1)-substituted derivatives of cis-piperazine-2,3-dicarboxylic acid display improved relative affinity for GluN2C and GluN2D versus GluN2A and GluN2...

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Main Authors: Irvine, Mark W., Costa, Blaise M., Dlaboga, Daniel, Culley, Georgia, Hulse, Richard, Scholefield, Caroline L., Atlason, Palmi, Fang, Guangyu, Eaves, Richard, Morley, Richard, Mayo-Martin, Maria B., Amici, Mascia, Bortolotto, Zuner A., Donaldson, Lucy, Collingridge, Graham L., Molnár, Elek, Monaghan, Daniel T., Jane, David E.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269097/
https://ncbi.nlm.nih.gov/pubmed/22111545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201230z
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