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Challenges of clinical trial design when there is lack of clinical equipoise: use of a response-conditional crossover design
Clinical equipoise is widely accepted as the basis of ethics in clinical research and requires investigators to be uncertain of the relative therapeutic merits of trial comparators. When clinical equipoise is in question, innovative trial designs are needed to reduce ethical tension while satisfying...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer-Verlag
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268968/ https://ncbi.nlm.nih.gov/pubmed/21822934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00415-011-6200-0 |
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