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Challenges of clinical trial design when there is lack of clinical equipoise: use of a response-conditional crossover design
Clinical equipoise is widely accepted as the basis of ethics in clinical research and requires investigators to be uncertain of the relative therapeutic merits of trial comparators. When clinical equipoise is in question, innovative trial designs are needed to reduce ethical tension while satisfying...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer-Verlag
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3268968/ https://ncbi.nlm.nih.gov/pubmed/21822934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00415-011-6200-0 |
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