A Novel Role for α-Tocopherol Transfer Protein (α-TTP) in Protecting against Chloroquine Toxicity

Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases. Clinical treatment with CQ is often accompanied by serious side effects such as hepatitis and retinopathy. As a weak base, CQ accumulates in intracellular acidic organelles, raises the pH...

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Autores principales: Shichiri, Mototada, Kono, Nozomu, Shimanaka, Yuta, Tanito, Masaki, Rotzoll, Daisy E., Yoshida, Yasukazu, Hagihara, Yoshihisa, Tamai, Hiroshi, Arai, Hiroyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Membrane Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268449/
https://ncbi.nlm.nih.gov/pubmed/22147702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.321281
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