A Generalized Sequential Bonferroni Procedure Using Smoothed Weights for Genome-Wide Association Studies Incorporating Information on Hardy-Weinberg Disequilibrium among Cases

BACKGROUND/OBJECTIVES: For genome-wide association studies (GWAS) with case-control designs, one of the most widely used association tests is the Cochran-Armitage (CA) trend test assuming an additive mode of inheritance. The CA trend test often has higher power than other association tests under add...

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Detalhes bibliográficos
Main Authors: Gao, Guimin, Kang, Guolian, Wang, Jiexun, Chen, Wenan, Qin, Huaizen, Jiang, Bo, Li, Qizhai, Sun, Chuanyu, Liu, Nianjun, Archer, Kellie J., Allison, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268348/
https://ncbi.nlm.nih.gov/pubmed/22212195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000332916
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