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Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine

Aminopropyltransferases are essential enzymes that form polyamines in eukaryotic and most prokaryotic cells. Spermidine synthase (SpdS) is one of the most well-studied enzymes in this biosynthetic pathway. The enzyme uses decarboxylated S-adenosylmethionine and a short-chain polyamine (putrescine) t...

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Autors principals: Šečkutė, Jolita, McCloskey, Diane E, Thomas, H Jeanette, Secrist, John A, Pegg, Anthony E, Ealick, Steven E
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267948/
https://ncbi.nlm.nih.gov/pubmed/21898642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.717
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