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Quantitating subcellular metabolism with multi-isotope imaging mass spectrometry

Mass spectrometry with stable isotope labels has been seminal in discovering the dynamic state of living matter(1,2) but is limited to bulk tissues or cells. We developed multi-isotope imaging mass spectrometry (MIMS) that allowed us to view and measure stable isotope incorporation with sub-micron r...

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Detalles Bibliográficos
Main Authors: Steinhauser, Matthew L., Bailey, Andrew, Senyo, Samuel E., Guillermier, Christelle, Perlstein, Todd S., Gould, Alex P., Lee, Richard T., Lechene, Claude P.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267887/
https://ncbi.nlm.nih.gov/pubmed/22246326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10734
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