Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines

BACKGROUND: The Anaplastic Lymphoma Kinase (ALK) is an orphan receptor tyrosine kinase, which undergoes post-translational N-linked glycosylation. The catalytic domain of ALK was originally identified in the t(2;5) translocation that produces the unglycosylated oncogenic protein NPM-ALK, which occur...

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Bibliografiske detaljer
Main Authors: Del Grosso, Federica, De Mariano, Marilena, Passoni, Lorena, Luksch, Roberto, Tonini, Gian Paolo, Longo, Luca
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267831/
https://ncbi.nlm.nih.gov/pubmed/22192458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-525
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