Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models

BACKGROUND: Immunosuppressive factors such as regulatory T cells (Tregs) limit the efficacy of immunotherapies. Histone deacetylase (HDAC) inhibitors have been reported to have antitumor activity in different malignancies and immunomodulatory effects. Herein, we report the Tregs-targeting and immune...

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Detalhes bibliográficos
Main Authors: Shen, Li, Ciesielski, Michael, Ramakrishnan, Swathi, Miles, Kiersten M., Ellis, Leigh, Sotomayor, Paula, Shrikant, Protul, Fenstermaker, Robert, Pili, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267747/
https://ncbi.nlm.nih.gov/pubmed/22303460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030815
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