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Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

It is of urgent need to identify the exact physico-chemical characteristics which allow maximum uptake and accumulation in secondary target organs of nanoparticulate drug delivery systems after oral ingestion. We administered radiolabelled gold nanoparticles in different sizes (1.4-200 nm) with nega...

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Detalhes bibliográficos
Main Authors: Schleh, Carsten, Semmler-Behnke, Manuela, Lipka, Jens, Wenk, Alexander, Hirn, Stephanie, Schäffler, Martin, Schmid, Günter, Simon, Ulrich, Kreyling, Wolfgang G
Formato: Artigo
Idioma:Inglês
Publicado em: Informa Healthcare 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3267526/
https://ncbi.nlm.nih.gov/pubmed/21309618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/17435390.2011.552811
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