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Discovery and Synthesis of Namalide Reveals a New Anabaenopeptin Scaffold and Peptidase Inhibitor

The discovery, structure elucidation and solid phase synthesis of namalide, a marine natural product, are described. Namalide is a cyclic tetrapeptide; its macrocycle is formed by only three amino acids, with an exocyclic ureido phenylalanine moiety at its C-terminus. The absolute configuration of n...

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Autores principales: Cheruku, Pradeep, Plaza, Alberto, Lauro, Gianluigi, Keffer, Jessica, Lloyd, John R., Bifulco, Giuseppe, Bewley, Carole A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266974/
https://ncbi.nlm.nih.gov/pubmed/22168797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201238p
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