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High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency

Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry. The polygenic nature of IgAD is underscored by the recent identification of several new risk gene...

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Bibliografiske detaljer
Main Authors: Ferreira, Ricardo C., Pan-Hammarström, Qiang, Graham, Robert R., Fontán, Gumersindo, Lee, Annette T., Ortmann, Ward, Wang, Ning, Urcelay, Elena, Fernández-Arquero, Miguel, Núñez, Concepción, Jorgensen, Gudmundur, Ludviksson, Björn R., Koskinen, Sinikka, Haimila, Katri, Padyukov, Leonid, Gregersen, Peter K., Hammarström, Lennart, Behrens, Timothy W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266887/
https://ncbi.nlm.nih.gov/pubmed/22291608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002476
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