Sildenafil Prevents and Reverses T-tubule Remodeling and Ca(2+) Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension

Right ventricular failure (RVF) is the main cause of death in patients with pulmonary artery hypertension (PAH). Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, was recently approved for treatment of PAH patients. However, the mechanisms underlying RV contractile malfunction and the benefit...

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Main Authors: Xie, Yu-Ping, Chen, Biyi, Sanders, Philip, Guo, Ang, Li, Yue, Zimmerman, Kathy, Wang, Lie-Cheng, Weiss, Robert M., Grumbach, Isabella M., Anderson, Mark E., Song, Long-Sheng
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266850/
https://ncbi.nlm.nih.gov/pubmed/22203744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.111.180968
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