Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

Genetic deletion of the mitochondrial deacetylase sirtuin-3 (Sirt3) results in increased mitochondrial superoxide, a tumor permissive environment, and mammary tumor development. MnSOD contains a nutrient- and ionizing radiation (IR)-dependent reversible acetyl-lysine that is hyperacetylated in Sirt3...

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Huvudupphovsmän: Tao, Randa, Coleman, Mitchell C., Pennington, Daniel, Ozden, Ozkan, Park, Seong-Hoon, Jiang, Haiyan, Kim, Hyun-Seok, Flynn, Charles Robb, Hill, Salisha, McDonald, W. Hayes, Olivier, Alicia K., Spitz, Douglas R., Gius, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266626/
https://ncbi.nlm.nih.gov/pubmed/21172655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.12.013
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