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Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells

Mycobacterium tuberculosis promotes its replication by inhibiting the apoptosis of infected macrophages. A proapoptotic M. tuberculosis mutant lacking nuoG, a subunit of the type I NADH dehydrogenase complex, exhibits attenuated growth in vivo, indicating that this virulence mechanism is essential....

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Autori principali: Blomgran, Robert, Desvignes, Ludovic, Briken, Volker, Ernst, Joel D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266554/
https://ncbi.nlm.nih.gov/pubmed/22264515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.11.012
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