Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett’s-like metaplasia

Esophageal adenocarcinoma (EAC) arises from Barrett esophagus (BE), intestinal-like columnar metaplasia linked to reflux esophagitis. In a transgenic mouse model of BE, esophageal overexpression of interleukin-1β phenocopies human pathology with evolution of esophagitis, Barrett’s-like metaplasia an...

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Hlavní autoři: Quante, Michael, Bhagat, Govind, Abrams, Julian, Marache, Frederic, Good, Pamela, Lee, Michele D., Lee, Yoomi, Friedman, Richard, Asfaha, Samuel, Dubeykovskaya, Zinaida, Mahmood, Umar, Figueiredo, Jose-Luiz, Kitajewski, Jan, Shawber, Carrie, Lightdale, Charles, Rustgi, Anil K., Wang, Timothy C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266546/
https://ncbi.nlm.nih.gov/pubmed/22264787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.12.004
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