Calcimimetic R-568 and Its Enantiomer S-568 Increase Nitric Oxide Release in Human Endothelial Cells

BACKGROUND: Calcimimetics, such as R-568, are thought to activate G protein-linked Ca(2+)-sensing receptor (CaSR) by allosterically increasing the affinity of the receptor for Ca(2+) allowing for efficient control of uremic hyperparathyroidism. Several recent studies suggest they possess additional...

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Autors principals: Bonomini, Mario, Giardinelli, Annalisa, Morabito, Caterina, Di Silvestre, Sara, Di Cesare, Moreno, Di Pietro, Natalia, Sirolli, Vittorio, Formoso, Gloria, Amoroso, Luigi, Mariggiò, Maria Addolorata, Pandolfi, Assunta
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266284/
https://ncbi.nlm.nih.gov/pubmed/22295103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030682
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