Genetic Profiling Using Genome-Wide Significant Coronary Artery Disease Risk Variants Does Not Improve the Prediction of Subclinical Atherosclerosis: The Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey – A Meta-Analysis of Three Independent Studies

BACKGROUND: Genome-wide association studies (GWASs) have identified a large number of variants (SNPs) associating with an increased risk of coronary artery disease (CAD). Recently, the CARDIoGRAM consortium published a GWAS based on the largest study population so far. They successfully replicated t...

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Main Authors: Hernesniemi, Jussi A., Seppälä, Ilkka, Lyytikäinen, Leo-Pekka, Mononen, Nina, Oksala, Niku, Hutri-Kähönen, Nina, Juonala, Markus, Taittonen, Leena, Smith, Erin N., Schork, Nicholas J., Chen, Wei, Srinivasan, Sathanur R., Berenson, Gerald S., Murray, Sarah S., Laitinen, Tomi, Jula, Antti, Kettunen, Johannes, Ripatti, Samuli, Laaksonen, Reijo, Viikari, Jorma, Kähönen, Mika, Raitakari, Olli T., Lehtimäki, Terho
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266236/
https://ncbi.nlm.nih.gov/pubmed/22295058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028931
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