MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF

MET, a receptor protein tyrosine kinase activated by hepatocyte growth factor (HGF), is a crucial determinant of metastatic progression. Recently, we have identified p53 as an important regulator of MET-dependent cell motility and invasion. This regulation occurs via feedforward loop suppressing MET...

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Hlavní autoři: Hwang, Chang-Il, Choi, Jinhyang, Zhou, Zongxiang, Flesken-Nikitin, Andrea, Tarakhovsky, Alexander, Nikitin, Alexander Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266114/
https://ncbi.nlm.nih.gov/pubmed/22071625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.10.22.18294
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