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Dynamics of Amyloid β Fibrils Revealed by Solid-state NMR

We have investigated the site-specific backbone dynamics of mature amyloid β (Aβ) fibrils using solid-state NMR spectroscopy. Overall, the known β-sheet segments and the turn linking these two β-strands exhibit high order parameters between 0.8 and 0.95, suggesting low conformational flexibility. Th...

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書誌詳細
主要な著者: Scheidt, Holger A., Morgado, Isabel, Rothemund, Sven, Huster, Daniel
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265881/
https://ncbi.nlm.nih.gov/pubmed/22130659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.308619
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