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Superhelicity induces hypersensitivity of a human polypyrimidine . polypurine DNA sequence in the human alpha 2-alpha 1 globin intergenic region to S1 nuclease digestion--high resolution mapping of the clustered cleavage sites.

Supercoiled recombinant DNAs containing the human adult alpha-globin gene region have been probed with nuclease S1 in vitro. While agarose gel electrophoresis showed only one predominant, double-stranded cleavage generated by S1 within 6 kb of human DNA and 4 kb of pBR322 sequence, a high resolution...

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Hlavní autor: Shen, C K
Médium: Artigo
Jazyk:Inglês
Vydáno: 1983
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC326548/
https://ncbi.nlm.nih.gov/pubmed/6316277
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