Expansion of CD8(+) T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity

Sema4D, also known as CD100, is a constitutively expressed immune semaphorin on T cells and NK cells. CD100 has important immune regulatory functions that improve antigen-specific priming by antigen-presenting cells, and can also act as a costimulatory molecule on T cells. We investigated the conseq...

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Hlavní autoři: Eriksson, Emily M., Milush, Jeffrey M., Ho, Emily L., Batista, Mariana D., Holditch, Sara J., Keh, Chris E., Norris, Philip J., Keating, Sheila M., Deeks, Steven G., Hunt, Peter W., Martin, Jeffrey N., Rosenberg, Michael G., Hecht, Frederick M., Nixon, Douglas F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265199/
https://ncbi.nlm.nih.gov/pubmed/22134167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-324848
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