Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor–2α

PURPOSE: Hypoxia is a critical pathological factor in a variety of retinal diseases, including age-related macular degeneration. It upregulates angiogenic growth factors and promotes neovascularization. Hypoxia changes the cellular redox state and activates class III histone deacetylase sirtuin1 (SI...

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Bibliographic Details
Main Authors: Balaiya, Sankarathi, Khetpal, Vijay, Chalam, Kakarla V.
Format: Artigo
Language:Inglês
Published: Molecular Vision 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265172/
https://ncbi.nlm.nih.gov/pubmed/22275802
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