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Atomic-level insights into metabolite recognition and specificity of the SAM-II riboswitch
Although S-adenosylhomocysteine (SAH), a metabolic by-product of S-adenosylmethionine (SAM), differs from SAM only by a single methyl group and an overall positive charge, SAH binds the SAM-II riboswitch with more than 1000-fold less affinity than SAM. Using atomistic molecular dynamics simulations,...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3264916/ https://ncbi.nlm.nih.gov/pubmed/22194311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.028779.111 |
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