Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors

Hypofunction of the N-methyl D-aspartate subtype of glutamate receptor (NMDAR) is hypothesized to be a mechanism underlying cognitive dysfunction in individuals with schizophrenia. For the schizophrenia-linked genes NRG1 and ERBB4, NMDAR hypofunction is thus considered a key detrimental consequence...

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Bibliographische Detailangaben
Hauptverfasser: Pitcher, Graham M, Kalia, Lorraine V, Ng, David, Goodfellow, Nathalie M, Yee, Kathleen T, Lambe, Evelyn K, Salter, Michael W
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264662/
https://ncbi.nlm.nih.gov/pubmed/21441918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2315
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