Limited Model Antigen Expression by Transgenic Fungi Induces Disparate Fates during Differentiation of Adoptively Transferred T Cell Receptor Transgenic CD4(+) T Cells: Robust Activation and Proliferation with Weak Effector Function during Recall

CD4(+) T cells are the key players of vaccine resistance to fungi. The generation of effective T cell-based vaccines requires an understanding of how to induce and maintain CD4(+) T cells and memory. The kinetics of fungal antigen (Ag)-specific CD4(+) T cell memory development has not been studied d...

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Autori principali: Wüthrich, Marcel, Ersland, Karen, Pick-Jacobs, John C., Gern, Benjamin H., Frye, Christopher A., Sullivan, Thomas D., Brennan, Meghan B., Filutowicz, Hanna I., O'Brien, Kevin, Korthauer, Keegan D., Schultz-Cherry, Stacey, Klein, Bruce S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264303/
https://ncbi.nlm.nih.gov/pubmed/22124658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05326-11
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