Synthesis and Inhibiting Activity of Some 4-Hydroxycoumarin Derivatives on HIV-1 Protease

Six novel 4-hydroxycoumarin derivatives were rationally synthesized, verified, and characterized by molecular docking using crystal HIV-1 protease. Molecular docking studies predicted antiprotease activity of (7) and (10). The most significant functional groups, responsible for the interaction with...

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Detalhes bibliográficos
Main Authors: Stanchev, Stancho, Jensen, Frank, Hinkov, Anton, Atanasov, Vasil, Genova-Kalou, Petia, Argirova, Radka, Manolov, Ilia
Formato: Artigo
Idioma:Inglês
Publicado em: International Scholarly Research Network 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263710/
https://ncbi.nlm.nih.gov/pubmed/22389842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2011/137637
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