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Nucleic Acid-Based Therapy Approaches for Huntington's Disease
Huntington's disease (HD) is caused by a dominant mutation that results in an unstable expansion of a CAG repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with t...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Hindawi Publishing Corporation
2012
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263636/ https://ncbi.nlm.nih.gov/pubmed/22288011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/358370 |
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