Pharmacogenomics of Maternal Tobacco Use: Metabolic Gene Polymorphisms and Risk of Adverse Pregnancy Outcomes

OBJECTIVE: To assess whether functional maternal or fetal genotypes along well-characterized metabolic pathways (ie, CYP1A1, GSTT1, and CYP2A6) may account for varying associations with adverse outcomes among pregnant women who smoke. METHODS: DNA samples from 502 smokers and their conceptuses, alon...

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Hauptverfasser: Aagaard-Tillery, Kjersti, Spong, Catherine Y., Thom, Elizabeth, Sibai, Baha, Wendel, George, Wenstrom, Katharine, Samuels, Philip, Simhan, Hyagriv, Sorokin, Yoram, Miodovnik, Menachem, Meis, Paul, O’Sullivan, Mary J., Conway, Deborah, Wapner, Ronald J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263385/
https://ncbi.nlm.nih.gov/pubmed/20177288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/AOG.0b013e3181d06faf
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