A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis

Interferon-γ (IFNγ) plays a major role during host defense against Mycobacterium tuberculosis (Mtb). T cells produce IFNγ in response to IL-12 and IL-18 secreted from Mtb infected macrophages. IFNγ in turn, induces nitric oxide secretion in macrophages that kills Mtb. IFNγ knock-out mice are thus hy...

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Detalhes bibliográficos
Main Authors: Mashruwala, Mary Anne, Smith, Amanda K., Lindsey, Devin R., Moczygemba, Margaret, Wetsel, Rick A., Klein, John R., Actor, Jeffrey K., Jagannath, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263371/
https://ncbi.nlm.nih.gov/pubmed/22154007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tube.2011.10.016
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