2,3-Dihydro-1-Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand-Steered Modeling

We recently discovered and reported a series of N-alkyl-isatin acylhydrazone derivatives that are potent cannabinoid receptor 2 (CB(2)) agonists. In an effort to improve the druglike properties of these compounds and to better understand and improve the treatment of neuropathic pain, we designed and...

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Detalhes bibliográficos
Main Authors: Diaz, Philippe, Phatak, Sharangdhar S., Xu, Jijun, Fronczek, Frank R., Astruc-Diaz, Fanny, Thompson, Charles M., Cavasotto, Claudio N., Naguib, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262993/
https://ncbi.nlm.nih.gov/pubmed/19637157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200900226
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