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Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NFκB nuclear accumulation in CD4 T cells
A key consequence of regulatory T cell (Treg) suppression of CD4 T cells is the inhibition of IL-2 production, yet how Tregs attenuate IL-2 has not been defined. Current models predict a termination of TCR signaling, by disrupting T-APC contacts, or TCR-signal modification, through mechanisms such a...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262913/ https://ncbi.nlm.nih.gov/pubmed/22227565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101027 |
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