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Regulatory T cells selectively attenuate, not terminate, T cell signaling by disrupting NFκB nuclear accumulation in CD4 T cells

A key consequence of regulatory T cell (Treg) suppression of CD4 T cells is the inhibition of IL-2 production, yet how Tregs attenuate IL-2 has not been defined. Current models predict a termination of TCR signaling, by disrupting T-APC contacts, or TCR-signal modification, through mechanisms such a...

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Bibliografiske detaljer
Main Authors: Huang, Yu-Hui, Sojka, Dorothy K., Fowell, Deborah J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262913/
https://ncbi.nlm.nih.gov/pubmed/22227565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101027
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