Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

Chlamydophila pneumoniae causes acute respiratory tract infections and has been associated with development of asthma and atherosclerosis. The production of IL-1β, a key mediator of acute and chronic inflammation, is regulated on a transcriptional level and additionally on a posttranslational level...

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Bibliografiske detaljer
Main Authors: Eitel, Julia, Meixenberger, Karolin, van Laak, Claudia, Orlovski, Christine, Hocke, Andreas, Schmeck, Bernd, Hippenstiel, Stefan, N'Guessan, Philippe Dje, Suttorp, Norbert, Opitz, Bastian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262829/
https://ncbi.nlm.nih.gov/pubmed/22276187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030379
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