Ezrin, Radixin, and Moesin Are Phosphorylated in Response to 2-Methoxyestradiol and Modulate Endothelial Hyperpermeability

We showed previously that microtubule disruptor 2-methoxyestradiol (2ME) induces hyperpermeability of the endothelial monolayer via mechanisms that include the activation of p38 and Rho kinase (ROCK) and rearrangement of the actin cytoskeleton. Using the protein kinase C (PKC) inhibitors Ro-31–7549...

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Detalhes bibliográficos
Main Authors: Bogatcheva, Natalia V., Zemskova, Marina A., Gorshkov, Boris A., Kim, Kyung Mi, Daglis, Gregory A., Poirier, Christophe, Verin, Alexander D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262663/
https://ncbi.nlm.nih.gov/pubmed/21659656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0092OC
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