Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

The clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters indicate that the inability to control parasite replication in VL could be related to ineffective classical macrophage activation. Therefore, we hyp...

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Detalhes bibliográficos
Main Authors: Osorio, E. Yaneth, Zhao, Weiguo, Espitia, Claudia, Saldarriaga, Omar, Hawel, Leo, Byus, Craig V., Travi, Bruno L., Melby, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261917/
https://ncbi.nlm.nih.gov/pubmed/22275864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002417
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