Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental Bullous Pemphigoid

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease associated with autoantibodies against the hemidesmosomal proteins BP180 and BP230. In the IgG passive transfer model of BP, blister formation is triggered by anti-BP180 IgG and depends on complement activation, mast cell degra...

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Main Authors: Lin, Lan, Betsuyaku, Tomoko, Heimbach, Lisa, Li, Ning, Rubenstein, David, Shapiro, Steven D., An, Lijia, Giudice, George J., Diaz, Luis A., Senior, Robert M., Liu, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261345/
https://ncbi.nlm.nih.gov/pubmed/21979170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2011.09.003
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