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Interleukin (IL)-10 ablation promotes tumor development, growth and metastasis

IL-10 is a broadly acting immune inhibitory cytokine that is generally thought to support tumor growth. Here we challenge this view with evidence that genetic ablation of IL-10 in the mouse significantly heightens sensitivity to chemical carcinogenesis, growth of transplanted tumors and formation of...

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Detalhes bibliográficos
Main Authors: Tanikawa, Takashi, Wilke, Cailin Moira, Kryczek, Ilona, Chen, Grace Y., Kao, John, Núñez, Gabriel, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261323/
https://ncbi.nlm.nih.gov/pubmed/22123924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4627
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