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Kaposi’s sarcoma herpesvirus oncogenesis is a Notch better in 3D
Culturing KSHV-infected lymphatic endothelial cells in 3D increases viral gene expression leading to Notch-induced MT1-MMP-dependent endothelial to mesenchymal transition. This reproduces patterns of KSHV gene expression and presence of mesenchymal KSHV-infected cells found in KS lesions, narrowing...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261213/ https://ncbi.nlm.nih.gov/pubmed/22177556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.11.008 |
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