Multiple-Clade H5N1 Influenza Split Vaccine Elicits Broad Cross Protection against Lethal Influenza Virus Challenge in Mice by Intranasal Vaccination

BACKGROUND: The increase in recent outbreaks and unpredictable changes of highly pathogenic avian influenza (HPAI) H5N1 in birds and humans highlights the urgent need to develop a cross-protective H5N1 vaccine. We here report our development of a multiple-clade H5N1 influenza vaccine tested for immu...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Penghui, Duan, Yueqiang, Zhang, Peirui, Li, Zhiwei, Wang, Cheng, Dong, Mei, Tang, Chong, Xing, Li, Gu, Hongjing, Zhao, Zhongpeng, Liu, Xiufan, Zhang, Shaogeng, Wang, Xiliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261182/
https://ncbi.nlm.nih.gov/pubmed/22279575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030252
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