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TLR5 Risk-Associated Haplotype for Canine Inflammatory Bowel Disease Confers Hyper-Responsiveness to Flagellin

Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease. We recently demonstrated a significant association between three non-synonymous SNPs in the canine TLR5 gene and IBD in German shepherd dogs (GSD...

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Autors principals: Kathrani, Aarti, Holder, Angela, Catchpole, Brian, Alvarez, Lorena, Simpson, Kenneth, Werling, Dirk, Allenspach, Karin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261174/
https://ncbi.nlm.nih.gov/pubmed/22279566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030117
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