Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT(1A) Receptor-Dependent Mechanism

The non-competitive NMDA receptor (NMDA-R) antagonist phencyclidine (PCP)—used as a pharmacological model of schizophrenia—disrupts prefrontal cortex (PFC) activity. PCP markedly increased the discharge rate of pyramidal neurons and reduced slow cortical oscillations (SCO; 0.15–4 Hz) in rat PFC. Bot...

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Detalhes bibliográficos
Main Authors: Kargieman, Lucila, Riga, Maurizio S, Artigas, Francesc, Celada, Pau
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260989/
https://ncbi.nlm.nih.gov/pubmed/22012474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.249
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