Reduced CD36-dependent tissue sequestration of Plasmodium-infected erythrocytes is detrimental to malaria parasite growth in vivo

Adherence of parasite-infected red blood cells (irbc) to the vascular endothelium of organs plays a key role in the pathogenesis of Plasmodium falciparum malaria. The prevailing hypothesis of why irbc adhere and sequester in tissues is that this acts as a mechanism of avoiding spleen-mediated cleara...

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Main Authors: Fonager, Jannik, Pasini, Erica M., Braks, Joanna A.M., Klop, Onny, Ramesar, Jai, Remarque, Edmond J., Vroegrijk, Irene O.C.M., van Duinen, Sjoerd G., Thomas, Alan W., Khan, Shahid M., Mann, Matthias, Kocken, Clemens H.M., Janse, Chris J., Franke-Fayard, Blandine M.D.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260870/
https://ncbi.nlm.nih.gov/pubmed/22184632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110762
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