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Transferred Antigen-Specific T(H)17 but not T(H)1 Cells Induce Crescentic Glomerulonephritis in Mice
To explore the role of antigen-specific CD4(+) T cells in glomerulonephritis, we administered ovalbumin 323–339 peptide conjugated to glomerular-binding polyclonal antibody and induced disease in RAG1(−/−) mice with CD4(+) T cells from OT2 × RAG1(−/−) mice. These OT2 × RAG1(−/−) mice have a transgen...
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Asıl Yazarlar: | , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
American Society for Investigative Pathology
2011
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3260861/ https://ncbi.nlm.nih.gov/pubmed/21983633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.017 |
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