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Transferred Antigen-Specific T(H)17 but not T(H)1 Cells Induce Crescentic Glomerulonephritis in Mice

To explore the role of antigen-specific CD4(+) T cells in glomerulonephritis, we administered ovalbumin 323–339 peptide conjugated to glomerular-binding polyclonal antibody and induced disease in RAG1(−/−) mice with CD4(+) T cells from OT2 × RAG1(−/−) mice. These OT2 × RAG1(−/−) mice have a transgen...

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Detaylı Bibliyografya
Asıl Yazarlar: Tulone, Calogero, Giorgini, Angela, Freeley, Simon, Coughlan, Alice, Robson, Michael Gregory
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260861/
https://ncbi.nlm.nih.gov/pubmed/21983633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.017
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