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Dynamics-Stability Relationships in Apo- and Holomyoglobin: A Combined Neutron Scattering and Molecular Dynamics Simulations Study

The removal of the heme group from myoglobin (Mb) results in a destabilization of the protein structure. The dynamic basis of the destabilization was followed by comparative measurements on holo- (holo-Mb) and apomyoglobin (apo-Mb). Mean-squared displacements (MSD) and protein resilience on the pico...

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Autori principali: Stadler, Andreas Maximilian, Pellegrini, Eric, Johnson, Mark, Fitter, Jörg, Zaccai, Giuseppe
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260689/
https://ncbi.nlm.nih.gov/pubmed/22339872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.12.031
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