Hydroimidazolone Modification of the Conserved Arg12 in Small Heat Shock Proteins: Studies on the Structure and Chaperone Function Using Mutant Mimics

Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modification of αA-crystallin increased its chaperone fu...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Nagaraj, Ram H., Panda, Alok Kumar, Shanthakumar, Shilpa, Santhoshkumar, Puttur, Pasupuleti, NagaRekha, Wang, Benlian, Biswas, Ashis
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2012
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260246/
https://ncbi.nlm.nih.gov/pubmed/22272318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030257
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