Hydroimidazolone Modification of the Conserved Arg12 in Small Heat Shock Proteins: Studies on the Structure and Chaperone Function Using Mutant Mimics

Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modification of αA-crystallin increased its chaperone fu...

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Detalhes bibliográficos
Main Authors: Nagaraj, Ram H., Panda, Alok Kumar, Shanthakumar, Shilpa, Santhoshkumar, Puttur, Pasupuleti, NagaRekha, Wang, Benlian, Biswas, Ashis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260246/
https://ncbi.nlm.nih.gov/pubmed/22272318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030257
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