Disruption of p16 and Activation of Kras in Pancreas Increase Ductal Adenocarcinoma Formation and Metastasis in vivo

Inactivation of tumor suppressor gene p16/INK4A and oncogenic activation of KRAS occur in almost all pancreatic cancers. To better understand the roles of p16 in pancreatic tumorigenesis, we created a conditional p16 knockout mouse line (p16(flox/flox)), in which p16 is specifically disrupted in a t...

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Detalhes bibliográficos
Main Authors: Qiu, Wanglong, Sahin, Fikret, Iacobuzio-Donahue, Christine A., Garcia-Carracedo, Dario, Wang, Wendy M., Kuo, Chia-Yu, Chen, Doris, Arking, Dan E., Lowy, Andrew M., Hruban, Ralph H., Remotti, Helen E., Su, Gloria H.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259996/
https://ncbi.nlm.nih.gov/pubmed/22113502
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