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The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function

Atg18 is essential for both autophagy and the regulation of vacuolar morphology. The latter process is mediated by phosphatidylinositol 3,5-bisphosphate binding, which is dispensable for autophagy. Atg18 also binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) in vitro. Here, we investigate the r...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Obara, Keisuke, Sekito, Takayuki, Niimi, Kaori, Ohsumi, Yoshinori
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259791/
https://ncbi.nlm.nih.gov/pubmed/18586673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803180200
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