S-Adenosyl-L-homocysteine Hydrolase, Key Enzyme of Methylation Metabolism, Regulates Phosphatidylcholine Synthesis and Triacylglycerol Homeostasis in Yeast: IMPLICATIONS FOR HOMOCYSTEINE AS A RISK FACTOR OF ATHEROSCLEROSIS

In eukaryotes, S-adenosyl-l-homocysteine hydrolase (Sah1) offers a single way for degradation of S-adenosyl-l-homocysteine, a product and potent competitive inhibitor of S-adenosyl-l-methionine (AdoMet)-dependent methyltransferases. De novophosphatidylcholine(PC)synthesisrequiresthreeAdoMet-dependen...

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Autori principali: Malanovic, Nermina, Streith, Ingo, Wolinski, Heimo, Rechberger, Gerald, Kohlwein, Sepp D., Tehlivets, Oksana
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259781/
https://ncbi.nlm.nih.gov/pubmed/18591246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800830200
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