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The H2A-H2B Dimeric Kinetic Intermediate is Stabilized by Widespread Hydrophobic Burial with Few Fully Native Interactions
The H2A-H2B histone heterodimer folds via monomeric and dimeric kinetic intermediates. Within ~5 ms, the H2A and H2B polypeptides associate in a nearly diffusion-limited reaction to form a dimeric ensemble, denoted I(2) and I(2)*, the latter being a sub-population characterized by a higher content o...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259194/ https://ncbi.nlm.nih.gov/pubmed/22137897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.11.032 |
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