Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum

BACKGROUND: Although Tim-3 & PD-L1 signaling pathways play important roles in negatively regulating immune responses, their roles in chlamydial infection have not been evaluated. METHODS: Neutralization antibodies targeting Tim-3 and PD-L1 were used to treat mice. Following an intravaginal infec...

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Main Authors: Peng, Bo, Lu, Chunxue, Tang, Lingli, Yeh, I-Tien, He, Zhimin, Wu, Yimou, Zhong, Guangming
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259114/
https://ncbi.nlm.nih.gov/pubmed/22168579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-11-347
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