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Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum
BACKGROUND: Although Tim-3 & PD-L1 signaling pathways play important roles in negatively regulating immune responses, their roles in chlamydial infection have not been evaluated. METHODS: Neutralization antibodies targeting Tim-3 and PD-L1 were used to treat mice. Following an intravaginal infec...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259114/ https://ncbi.nlm.nih.gov/pubmed/22168579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-11-347 |
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